Nanotechnology in gene therapy
Application for Treatment
 
Nanotechnology in gene therapy

The disease usually affects not all cells of the body, but only some of their parts. However, after the medicationinto the body, they are dissolved in the blood with the blood flow and begin to act on all the cells, without exception, including for healthy.

Drugs acting on the disease unaffected cells can cause side effects, allergic reactions or simply harm them.That's why scientists are developing methods of treatment point. This will give the opportunity to work directlyonly on diseased cells without affecting healthy. Ie drugs are targeted and delivered in small doses.

There project nanocapsules which can adhere to specific cells. These microcapsules may well be the solution to this problem in medicine.

The only thing that prevents the use of such capsules for targeted drug delivery - a sensitive immune system.Once the immune cells are found with foreign bodies, including nanoparticles and drugs, they immediately try todestroy them, and completely removed from the body. And the more effective they will do it, the stronger will beour immunity. Therefore, if you enter into the blood nanocapsules with medications likely before they reachtargeted cells, our immune system to destroy them.

To circumvent the immune system, scientists suggest applying blood cells as delivery nanocapsules. The immune system is easy to recognize his relatives and never will attack the red blood cells. Therefore, if they areattached nanocapsules, our body recognizes them, will not check their surface. And erythrocyte attached thereto nanocapsules held on. So, get to those cells, which were addressed to the capsule.

Gene therapy and nanotechnology

In addition, the bacterium can be even simpler to implement such nanocapsules, and in this case it will have tooperate as a drug delivery to cells. In one such bacteria can attach more than hundreds of different types ofnanoparticles. Thus, it turns out that the bacteria - which is a real candidacy for drug delivery due to their ability to penetrate into living cells. Recently, it became particularly valuable application of nanotechnology in gene therapy, where you need to deliver DNA to the recipient, without destroying the healthy cell.

Gene therapy - a treatment as acquired and inherited diseases by administering to a patient's cell genetic elements as the recovery or destruction of gene function.

There are two methods of administration of the genetic information in an organism that has undergone various diseases. In the first case the cell is taken from the body, it introduced the necessary genetic information andthen return again to the place. In the latter case - the gene delivery takes place directly into the body directly,without extracting it with any of the cells.

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